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Article

The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1.

The Journal of biological chemistry - 7 Jan 2005

Fan Chun-Yang, Ren Hong-Yu, Lee Paul, Caplan Avrom J, Cyr Douglas M

Abstract excerpt

The cytosolic yeast Hsp40 Ydj1 contains a conserved zinc finger-like region (ZFLR), which has two zinc-binding domains (ZBD), that helps regulate and specify Hsp70 function. To investigate the mechanism for Ydj1 ZFLR action, ZBDI and ZBDII mutants were constructed and characterized. ZBDII mutants exhibited temperature-sensitive growth defects, but yeast tolerated mutation of ZBDI. However, ZBDI and ZBDII mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15496404
DOI: 10.1074/jbc.M410645200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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