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Article

Nucleotide variations amongst V(H)Genes of AMA-producing B cell clones in primary biliary cirrhosis.

Journal of autoimmunity - 1 May 2000

Fukushima N, Ikematsu H, Nakamura M, Matsui M, Shimoda S, Hayashida K, Niho Y, Koike K, Gershwin M E, Ishibashi H

Abstract excerpt

Primary biliary cirrhosis, a chronic liver disease characterized by progressive inflammatory destruction of intrahepatic bile ducts, is also characterized by the presence of antimitochondrial antibodies (AMA). The predominant autoantibody is directed at the E2 component of pyruvate dehydrogenase (PDC-E2). Recent studies of this autoantibody response have analysed immunoglobulin-variable regions of human...

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Identifiers

PMID: 10756087
DOI: 10.1006/jaut.2000.0366

Genes

PDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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