Article
Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency.
Journal of virology - 1 May 2000
Rinaldo C R, Huang X L, Fan Z, Margolick J B, Borowski L, Hoji A, Kalinyak C, McMahon D K, Riddler S A, Hildebrand W H, Day R B, Mellors J W
Abstract excerpt
The long-term efficacy of combination antiretroviral therapy may relate to augmentation of anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-cell responses. We found that prolonged treatment of late-stage HIV-1-infected patients with a protease inhibitor and two nucleoside reverse transcriptase inhibitors failed to restore sustained, high levels of HIV-1-specific, HLA class I-restricted,...
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