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Article

Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1.

Nucleic acids research - 1 Jun 2002

Higaki Yuji, Schullery Daniel, Kawata Yasunobu, Shnyreva Maria, Abrass Christine, Bomsztyk Karol

Abstract excerpt

Laminin is a multifunctional heterotrimeric protein present in extracellular matrix where it regulates processes that compose tissue architecture including cell differentiation. Laminin gamma1 is the most widely expressed laminin chain and its absence causes early lethality in mouse embryos. Laminin gamma1 chain gene (LAMC1) promoter contains several GC/GT-rich motifs including the bcn-1 element. Using the bcn-1...

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Source

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Identifiers

PMID: 12034813
DOI: 10.1093/nar/30.11.2270
PMCID: PMC117209

Genes

LAMC1
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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