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Article

Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster.

The Journal of cell biology - 3 Apr 2000

Inoue Y H, do Carmo Avides M, Shiraki M, Deak P, Yamaguchi M, Nishimoto Y, Matsukage A, Glover D M

Abstract excerpt

We describe a Drosophila gene, orbit, that encodes a conserved 165-kD microtubule-associated protein (MAP) with GTP binding motifs. Hypomorphic mutations in orbit lead to a maternal effect resulting in branched and bent mitotic spindles in the syncytial embryo. In the larval central nervous system, such mutants have an elevated mitotic index with some mitotic cells showing an increase in ploidy. Amorphic alleles...

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Source

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Identifiers

PMID: 10747094
DOI: 10.1083/jcb.149.1.153
PMCID: PMC2175100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster.PMID 10747094Read ↗

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