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Article

Mitotic misregulation and human aging.

Science (New York, N.Y.) - 31 Mar 2000

Ly D H, Lockhart D J, Lerner R A, Schultz P G

Abstract excerpt

Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic...

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Identifiers

PMID: 10741968
DOI: 10.1126/science.287.5462.2486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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