Article
What can progeroid syndromes tell us about human aging?
Science (New York, N.Y.) - 3 Sept 2004
Kipling David, Davis Terence, Ostler Elizabeth L, Faragher Richard G A
Abstract excerpt
Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence...
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