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Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?

15 May 2019

Abstract excerpt

increases the proliferative activity, H3K9me3, and HP1, and decreases the senescence markers p21, IGFBP3, and GADD45B to the levels of young donor cells. Thus, progerin-dependent mechanisms act in natural aging. Excessive activity of the same mechanisms may well be the cause of premature aging in HGPS. Telomere attrition is widely regarded to be one of the primary hallmarks of aging. Progerin expression in normal...

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PMID: 31156709
DOI: 10.3389/fgene.2019.00455

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