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Article

A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides.

FEBS letters - 24 Mar 2000

Vais H, Atkinson S, Eldursi N, Devonshire A L, Williamson M S, Usherwood P N

Abstract excerpt

Two amino acid substitutions in a housefly sodium channel, L1014F in domain IIS6 and M918T in the IIS4-S5 linker, have been identified in kdr and super-kdr pyrethroid-resistant phenotypes, respectively. Unlike their native insect counterparts, mammalian sodium channels are only weakly sensitive to pyrethroids. Do the sodium channels of mammal and pyrethroid-resistant housefly share similar structural...

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PMID: 10734222
DOI: 10.1016/s0014-5793(00)01305-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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