Article
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2008
Rodriguez Rene, Hansen Lasse Tengbjerg, Phear Geraldine, Scorah Jennifer, Spang-Thomsen Mogens, Cox Angela, Helleday Thomas, Meuth Mark
Abstract excerpt
PURPOSE: DNA synthesis inhibitors and damaging agents are widely used in cancer therapy; however, sensitivity of tumors to such agents is highly variable. The response of tumor cells in culture to these agents is strongly influenced by the status of DNA damage response pathways. Here, we attempt to exploit the altered response of mismatch repair (MMR)-deficient colon cancer cells and tumors to camptothecin or...
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