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Article

Uncovering genetic relationships using small molecules that selectively target yeast cell cycle mutants.

Chemical biology & drug design - 1 Apr 2007

Nehil Michael T, Tamble Craig M, Combs David J, Kellogg Douglas R, Lokey R Scott

Abstract excerpt

Genetic analysis in budding yeast has shown that multiple G1 cyclins and cyclin-dependent kinases control cell cycle entry, polarized growth, and spindle pole duplication. The G1 cyclins Cln1 and Cln2 associate with the cyclin-dependent kinase Cdc28 to facilitate cell cycle progression and development of the cleavage apparatus. We have developed a chemical genetic approach toward the discovery of compounds that...

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PMID: 17461973
DOI: 10.1111/j.1747-0285.2007.00496.x

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