Article
Histogenesis of the cerebral cortex in rat fetuses with a mutation in the Pax-6 gene.
Brain research. Developmental brain research - 15 Mar 2000
Fukuda T, Kawano H, Osumi N, Eto K, Kawamura K
Abstract excerpt
The embryonic development of the cerebral cortex was histologically examined in rat homozygotes with a mutation of the Paired box (Pax)-6 gene, rat Small eye (rSey(2)/rSey(2)). Although the cerebral wall was thinner in rSey(2)/rSey(2) than in the wild type at embryonic day 16 (E16), cortical cells of mutants labeled with 5'-bromodeoxyuridine (BrdU) at E13 migrated as normal, settling in superficial layer at E16....
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