Article
Evaluation of three polymorphisms in the promoter region of the angiotensin II type I receptor gene.
Journal of hypertension - 1 Mar 2000
Zhang X, Erdmann J, Regitz-Zagrosek V, Kürzinger S, Hense H W, Schunkert H
Abstract excerpt
BACKGROUND: Angiotensin II induces vasoconstriction and growth via stimulation of the AT1 receptor. A genetic variant (+1166A/C) in the 3' untranslated region of this gene had been found to be associated with arterial hypertension, aortic stiffness and coronary artery disease. OBJECTIVE: In order to evaluate further the potential implications of the genetic variability of the AT1 gene we explored three newly...
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