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Article

Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress.

Biochemical and biophysical research communications - 28 Mar 2008

Kobayashi Yoshifumi, Inai Tomomi, Mizunuma Masaki, Okada Ichitaro, Shitamukai Atsunori, Hirata Dai, Miyakawa Tokichi

Abstract excerpt

In the yeast Saccharomyces cerevisiae, Tup1, in association with Cyc8 (Ssn6), functions as a general transcriptional corepressor. This repression is mediated by recruitment of the Tup1-Cyc8 complex to target promoters through sequence-specific DNA-binding proteins such as Sko1, which mediates the HOG pathway-dependent regulation. We identified tup1 and cyc8 mutant alleles as the suppressor of osmo-sensitivity of...

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PMID: 18201562
DOI: 10.1016/j.bbrc.2008.01.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress.PMID 18201562Read ↗

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