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Article

Identification of Cryptosporidium parvum dihydrofolate reductase inhibitors by complementation in Saccharomyces cerevisiae.

Antimicrobial agents and chemotherapy - 1 Apr 2000

Brophy V H, Vasquez J, Nelson R G, Forney J R, Rosowsky A, Sibley C H

Abstract excerpt

There is a pressing need for drugs effective against the opportunistic protozoan pathogen Cryptosporidium parvum. Folate metabolic enzymes and enzymes of the thymidylate cycle, particularly dihydrofolate reductase (DHFR), have been widely exploited as chemotherapeutic targets. Although many DHFR inhibitors have been synthesized, only a few have been tested against C. parvum. To expedite and facilitate the...

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Identifiers

PMID: 10722506
DOI: 10.1128/AAC.44.4.1019-1028.2000
PMCID: PMC89807

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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