Article
Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995
Volkman S K, Cowman A F, Wirth D F
Abstract excerpt
The pfmdr1 gene has been associated with a drug-resistant phenotype in Plasmodium falciparum, and overexpression of pfmdr1 has been associated with mefloquine- and halofantrine-resistant parasites, but little is known about the functional role of pfmdr1 in this process. Here, we demonstrate that...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Animals
- Biological Transport
- Blotting, Northern
- Chloroquine
- Drug Resistance
- Fluorescent Antibody Technique
- Fungal Proteins
- Genes, Fungal
- Genes, Protozoan
- Genetic Complementation Test
- Glycoproteins
- Mating Factor
- Molecular Sequence Data
- Mutation
- Peptides