Article
Strong association, but incomplete correlation, between chloroquine resistance and allelic variation in the pfmdr-1 gene of Plasmodium falciparum isolates from India.
Annals of tropical medicine and parasitology - 1 Oct 1999
Bhattacharya P R, Pillai C R
Abstract excerpt
The increasing prevalence of chloroquine-resistant Plasmodium falciparum has complicated the control of falciparum malaria. It has been suggested that point mutations at nucleotide positions 754, 1049, 3598, 3622 and 4234 in the parasite's pfmdr-1 gene are associated with such resistance, although this is a matter of controversy. Eighteen chloroquine-sensitive and 22 resistant isolates of P. falciparum from India...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Antimalarials
- Chloroquine
- India
- Insecticide Resistance
- Plasmodium falciparum
- Point Mutation
- Protozoan Proteins