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Article

Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity.

Oncogene - 28 Nov 2002

Miranda Claudia, Zanotti Giuseppe, Pagliardini Sonia, Ponzetto Carola, Pierotti Marco A, Greco Angela

Abstract excerpt

Activation of tyrosine kinase receptors is associated with human tumors. Tumorigenic versions of several RTKs, such as Ret, Kit and Met carry activating mutations at highly conserved residues of the tyrosine kinase domain. We have investigated the effect of some of these mutations on the NTRK1/NGF receptor, for which no naturally occurring activating point mutations have been so far detected. We introduced the...

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Source

Identifiers

PMID: 12447696
DOI: 10.1038/sj.onc.1206052

Genes

NTRK1
NGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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