Article
Mice maintain predominantly maternal Gαs expression throughout life in brown fat tissue (BAT), but not other tissues.
Bone - 1 Oct 2017
Tafaj Olta, Hann Steven, Ayturk Ugur, Warman Matthew L, Jüppner Harald
Abstract excerpt
The murine Gnas (human GNAS) locus gives rise to Gαs and different splice variants thereof. The Gαs promoter is not methylated thus allowing biallelic expression in most tissues. In contrast, the alternative first Gnas/GNAS exons and their promoters undergo parent specific methylation, which limits transcription to the non-methylated allele. Pseudohypoparathyroidism type Ia (PHP1A) or type Ib (PHP1B) are caused...
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