Article
Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities.
Journal of periodontal research - 1 Feb 2015
Wu X, Offenbacher S, Lόpez N J, Chen D, Wang H-Y, Rogus J, Zhou J, Beck J, Jiang S, Bao X, Wilkins L, Doucette-Stamm L, Kornman K
Abstract excerpt
BACKGROUND AND OBJECTIVE: Genetic markers associated with disease are often non-functional and generally tag one or more functional "causative" variants in linkage disequilibrium. Markers may not show tight linkage to the causative variants across multiple ethnicities due to evolutionary divergence, and therefore may not be informative across different population groups. Validated markers of disease suggest...
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