Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity.

doi:10.1177/1470320318761725

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Article

Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Jan 2000

Alves Cléber Rene, Fernandes Tiago, Lemos José Ribeiro, Magalhães Flávio de Castro, Trombetta Ivani Credidio, Alves Guilherme Barreto, Mota Glória de Fátima Alves da, Dias Rodrigo Gonçalves, Pereira Alexandre Costa, Krieger José Eduardo, Negrão Carlos Eduardo, Oliveira Edilamar Menezes

Abstract excerpt

INTRODUCTION: Previous studies have linked angiotensin-converting enzyme ( ACE) insertion (I)/deletion (D) polymorphism (II, ID and DD) to physical performance. Moreover, ACE has two catalytic domains: NH2 (N) and COOH (C) with distinct functions, and their activity has been found to be modulated by ACE polymorphism. The aim of the present study is to investigate the effects of the interaction between aerobic...

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PMID: 29629833
DOI: 10.1177/1470320318761725
PMCID: PMC5894927

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