Article
Craf-1 protein kinase is essential for mouse development.
Mechanisms of development - 1 Aug 1998
Wojnowski L, Stancato L F, Zimmer A M, Hahn H, Beck T W, Larner A C, Rapp U R, Zimmer A
Abstract excerpt
The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from a variety of cell surface receptors to the nucleus. We report here that Craf-1 is essential for mouse development, as its mutation results in embryonic lethality. De...
Topics
- Abnormalities, Multiple
- Animals
- Base Sequence
- Cell Division
- Fetal Death
- Fibroblasts
- Gene Expression Regulation, Developmental
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Proteins
- Species Specificity
- TNF Receptor-Associated Factor 3