Article
Craf-1 protein kinase is essential for mouse development.
Mechanisms of development - 1 Aug 1998
Wojnowski L, Stancato L F, Zimmer A M, Hahn H, Beck T W, Larner A C, Rapp U R, Zimmer A
Abstract excerpt
The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from a variety of cell surface receptors to the nucleus. We report here that Craf-1 is essential for mouse development, as its mutation results in embryonic lethality. Developmental defects are found in mutant placentas as well as in the skin and in the lungs of mutant embryos. Craf-1...
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