Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex.

Brain research - 28 Feb 2000

Itami C, Mizuno K, Kohno T, Nakamura S

Abstract excerpt

The maturation of cortical circuitry critically depends on experience. Recently, a model of silent synapse has been proposed as a mechanism of activity-mediated transition of immature synapse to mature synapse. It is not clear, however, how activity could regulate this transition. Here, we show the evidence that endogenous brain-derived neurotrophic factor (BDNF) is required for the maturation of glutamatergic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Growth Factors

Share to Neural Pathways

Share to Receptors, AMPA

Share to Somatosensory Cortex

Share to Synapses

Share to Thalamus

Source

Identifiers

PMID: 10700561
DOI: 10.1016/s0006-8993(99)02352-5

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex.PMID 10700561Read ↗

The Role of BDNF in the Development of Fear Learning.Semantic proximity Read ↗

Anatomical plasticity of adult brain is titrated by Nogo Receptor 1.Semantic proximity Read ↗

Prolonged anesthesia alters brain synaptic architectureSemantic proximity Read ↗

Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus.Semantic proximity Read ↗

Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out mice.Semantic proximity Read ↗

Serotonin controls the maturation of the GABA phenotype in the ventral spinal cord via 5-HT1b receptors.Semantic proximity Read ↗

A transient postnatal quiescent period precedes emergence of mature cortical dynamics.Semantic proximity Read ↗

Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and InhibitionSemantic proximity Read ↗

Enhanced Thalamocortical Synaptic Transmission and Dysregulation of the Excitatory-Inhibitory Balance at the Thalamocortical Feedforward Inhibitory Microcircuit in a Genetic Mouse Model of Migraine.Semantic proximity Read ↗

TrkB signaling regulates the developmental maturation of the somatosensory cortex.Semantic proximity Read ↗

Altered zincergic innervation of the developing primary somatosensory cortex in monoamine oxidase-A knockout mice.Semantic proximity Read ↗

Developmental increase of asynchronic glutamate release from hippocampal synapses in mutant taiep rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.