Mutation analysis of EP300 in colon, breast and ovarian carcinomas.

doi:10.1002/ijc.10682

Article

Mutation analysis of EP300 in colon, breast and ovarian carcinomas.

International journal of cancer - 10 Nov 2002

Bryan Emma J, Jokubaitis Venta J, Chamberlain Narelle L, Baxter Simon W, Dawson Elisabeth, Choong David Y H, Campbell Ian G

Abstract excerpt

The putative tumour suppressor gene EP300 is located on chromosome 22q13 which is a region showing frequent loss of heterozygosity (LOH) in colon, breast and ovarian cancers. We analysed 203 human breast, colon and ovarian primary tumours and cell lines for somatic mutations in EP300. LOH across the EP300 locus was detected in 38% of colon, 36% of breast, and 49% of ovarian primary tumours but no somatic...

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