Article
A functional analysis of a natural variant of intercellular adhesion molecule-1 (ICAM-1Kilifi).
Human molecular genetics - 1 Mar 2000
Craig A, Fernandez-Reyes D, Mesri M, McDowall A, Altieri D C, Hogg N, Newbold C
Abstract excerpt
Intercellular adhesion molecule-1 (ICAM-1) is involved in a range of interactions both within the host and between the host and a number of pathogens. Recently we described a mutation within the coding region of the first N-terminal immunoglobulin-like domain of ICAM-1, present at high frequency within African populations, which increased the risk of cerebral malaria. To understand the mechanism by which such a...
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