Identification and Characterization of a Bile Acid 7α-Dehydroxylation Operon in <i>Clostridium</i> sp. Strain TO-931, a Highly Active 7α-Dehydroxylating Strain Isolated from Human Feces

Abstract excerpt

Clostridium sp. strain TO-931 can rapidly convert the primary bile acid cholic acid to a potentially toxic compound, deoxycholic acid. Mixed oligonucleotide probes were used to isolate a gene fragment encoding a putative bile acid transporter from Clostridium sp. strain TO-931. This DNA fragment had 60% nucleotide sequence identity to a known bile acid transporter gene from Eubacterium sp. strain VPI 12708,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Molecular Research
• Share to Drug Transport and Resistance Mechanisms
• Share to Folate and B Vitamins Research