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Article

Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2.

PloS one - 1 Jan 2012

Bao Huan, Duong Franck

Abstract excerpt

The maltose transporter MalFGK(2), together with the substrate-binding protein MalE, is one of the best-characterized ABC transporters. In the conventional model, MalE captures maltose in the periplasm and delivers the sugar to the transporter. Here, using nanodiscs and proteoliposomes, we instead find that MalE is bound with high-affinity to MalFGK2 to facilitate the acquisition of the sugar. When the maltose...

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Identifiers

PMID: 22529943
DOI: 10.1371/journal.pone.0034836
PMCID: PMC3328499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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