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Article

MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator malt by antagonizing inducer binding.

The Journal of biological chemistry - 6 Aug 2004

Joly Nicolas, Böhm Alex, Boos Winfried, Richet Evelyne

Abstract excerpt

MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, has long been known to control negatively the activity of MalT, a transcriptional activator dedicated to the maltose regulon. By using a biochemical approach and the soluble form of MalK as a model substrate, we demonstrate that MalK alone inhibits transcription activation by MalT in a purified transcription system. The...

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Identifiers

PMID: 15180985
DOI: 10.1074/jbc.M403615200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator malt by antagonizing inducer binding.PMID 15180985Read ↗

Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.Semantic proximity Read ↗

The ATP-binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon.Semantic proximity Read ↗

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.Semantic proximity Read ↗

The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY.Semantic proximity Read ↗

Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.Semantic proximity Read ↗

MalFGK complex assembly and transport and regulatory characteristics of MalK insertion mutants.Semantic proximity Read ↗

Multiple protein-DNA and protein-protein interactions are involved in transcriptional activation by MalT.Semantic proximity Read ↗

Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.Semantic proximity Read ↗

Domain structure of the ATP-binding-cassette protein MalK of salmonella typhimurium as assessed by coexpressed half molecules and LacK'-'MalK chimeras.Semantic proximity Read ↗

Mutation of a single MalK subunit severely impairs maltose transport activity in Escherichia coli.Semantic proximity Read ↗

The ATP-binding cassette (ABC) transporter for maltose/maltodextrins of Salmonella typhimurium. Characterization of the ATPase activity associated with the purified MalK subunit.Semantic proximity Read ↗

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system.Semantic proximity Read ↗

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