Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.

doi:10.1128/jb.172.4.1846-1852.1990

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Article

Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.

Journal of bacteriology - 1 Apr 1990

Dardonville B, Raibaud O

Abstract excerpt

The expression of the maltose regulon of Escherichia coli is controlled by a transcriptional activator, the product of the malT gene, and is induced by the presence of maltose or maltodextrins in the growth medium. We isolated eight mutants with mutations in malT which lead to constitutive expression of the regulon. The nucleotide sequences of the mutated genes revealed that the eight mutations are clustered in...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Chromosome Mapping
Cloning, Molecular
DNA-Binding Proteins
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Genes, Regulator
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Maltose

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Restriction Mapping

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 2180908
DOI: 10.1128/jb.172.4.1846-1852.1990
PMCID: PMC208678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2180908-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.PMID 2180908Read ↗

The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY.Semantic proximity Read ↗

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.Semantic proximity Read ↗

Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.Semantic proximity Read ↗

Multiple protein-DNA and protein-protein interactions are involved in transcriptional activation by MalT.Semantic proximity Read ↗

The ATP-binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon.Semantic proximity Read ↗

Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.Semantic proximity Read ↗

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system.Semantic proximity Read ↗

MalK, the ATP-binding cassette component of the Escherichia coli maltodextrin transporter, inhibits the transcriptional activator malt by antagonizing inducer binding.Semantic proximity Read ↗

The MalT-dependent and malZ-encoded maltodextrin glucosidase of Escherichia coli can be converted into a dextrinyltransferase by a single mutation.Semantic proximity Read ↗

The role of the trehalose system in regulating the maltose regulon of Escherichia coli.Semantic proximity Read ↗

A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium.Semantic proximity Read ↗

Maltose and maltotriose can be formed endogenously in Escherichia coli from glucose and glucose-1-phosphate independently of enzymes of the maltose system.Semantic proximity Read ↗

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