Article
PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis.
Clinical and experimental immunology - 1 Mar 2000
Tay G K, Hui J, Gaudieri S, Schmitt-Egenolf M, Martinez O P, Leelayuwat C, Williamson J F, Eiermann T H, Dawkins R L
Abstract excerpt
The susceptibility genes for psoriasis remain to be identified. At least one of these must be in the major histocompatibility complex (MHC) to explain associations with alleles at human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and C4. In fact, most of these alleles are components of just two ancestral haplotypes (AHs) designated 13.1 and 57.1. Although relevant MHC gene(s) could be within a region of at least...
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