Article
Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells.
Vaccine - 25 Feb 2000
Lung T L, Saurwein-Teissl M, Parson W, Schönitzer D, Grubeck-Loebenstein B
Abstract excerpt
Dendritic cells (DC) are powerful antigen presenting cells, which have the unique capacity to stimulate naive T cells. In spite of the well-known decline of T cell function in old age, little information is available on whether DC are also affected by the aging process. This is mainly due to problems with the isolation and purification of DC. Rapid progress in the characterization of DC has been made in recent...
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