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Article

Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma.

Human pathology - 1 Nov 2016

Babkair Hamzah, Yamazaki Manabu, Uddin Md Shihab, Maruyama Satoshi, Abé Tatsuya, Essa Ahmed, Sumita Yoshimasa, Ahsan Md Shahidul, Swelam Wael, Cheng Jun, Saku Takashi

Abstract excerpt

We reported that altered cell contact mediated by E-cadherin is an initial event in the pathogenesis of oral epithelial malignancies. To assess other effects of cell adhesion, we examined the expression levels of tight junction (TJ) molecules in oral carcinoma in situ (CIS) and squamous cell carcinoma (SCC). To identify changes in the expression of TJ molecules, we conducted an analysis of the immunohistochemical...

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PMID: 27436828
DOI: 10.1016/j.humpath.2016.07.001

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