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Article

Occludin Is a Direct Target of Thyroid Transcription Factor-1 (TTF-1/NKX2–1)

3 Jul 2012

Abstract excerpt

The thyroid transcription factor 1 gene (TTF-1 or NKX2-1) is essential to lung development; however, it is also a critical factor in lung cancer. TTF-1 is amplified in lung cancers, suggesting that it is a gain-of-function lung oncogene. Conversely, TTF-1 counters epithelial to mesenchymal transition in cell-based studies and inhibits progression of primary lung adenocarcinomas to metastases in an animal model of...

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PMID: 22761434
DOI: 10.1074/jbc.m112.367987

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