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Article

The second loop of occludin is required for suppression of Raf1-induced tumor growth.

Oncogene - 23 Jun 2005

Wang Zili, Mandell Kenneth J, Parkos Charles A, Mrsny Randall J, Nusrat Asma

Abstract excerpt

Tight junctions (TJs) regulate epithelial cell polarity and paracellular permeability. Loss of functional TJs is commonly associated with epithelial cell-derived cancers. Raf1-mediated transformation of rat salivary gland epithelial cells (Pa4-Raf1) induces transcriptional downregulation of the TJ protein occludin and forced re-expression of occludin rescues polarized phenotype of epithelial cells. In the present...

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Identifiers

PMID: 15806147
DOI: 10.1038/sj.onc.1208634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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