Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3.

The Journal of biological chemistry - 25 Feb 2000

Leo C, Li H, Chen J D

Abstract excerpt

Steroid and nuclear receptor coactivators (NCoAs) have been implicated in the regulation of nuclear receptor function by enhancing ligand-dependent transcriptional activation of target gene expression. We have previously isolated receptor-associated coactivator 3 (RAC3), which belongs to the steroid receptor coactivator family. In this study, we investigated the differential mechanisms by which RAC3 interacts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Binding, Competitive
Share to Estrogen Receptor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptides

Share to Receptors, Calcitriol

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Estrogen

Share to Trans-Activators

Source

Identifiers

PMID: 10681591
DOI: 10.1074/jbc.275.8.5976

Genes

RAC3
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3.PMID 10681591Read ↗

Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.Semantic proximity Read ↗

Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.Semantic proximity Read ↗

Progesterone Receptors (PR)-B and -A Regulate Transcription by Different Mechanisms: AF-3 Exerts Regulatory Control over Coactivator Binding to PR-BSemantic proximity Read ↗

Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.Semantic proximity Read ↗

Three amino acids specify coactivator choice by retinoid X receptors.Semantic proximity Read ↗

The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.Semantic proximity Read ↗

Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators.Semantic proximity Read ↗

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.Semantic proximity Read ↗

Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain.Semantic proximity Read ↗

The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.Semantic proximity Read ↗

Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts.Semantic proximity Read ↗

Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.