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Article

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

18 Feb 2000

Abstract excerpt

Accelerated telomere loss has been proposed to be a factor leading to end-stage organ failure in chronic diseases of high cellular turnover such as liver cirrhosis. To test this hypothesis directly, telomerase-deficient mice, null for the essential telomerase RNA (mTR) gene, were subjected to genetic, surgical, and chemical ablation of the liver. Telomere dysfunction was associated with defects in liver...

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PMID: 10678830
DOI: 10.1126/science.287.5456.1253

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