Telomerase gene mutations are associated with cirrhosis formation.

doi:10.1002/hep.24217

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Article

Telomerase gene mutations are associated with cirrhosis formation.

Hepatology (Baltimore, Md.) - 1 May 2011

Hartmann Daniel, Srivastava Ujala, Thaler Michaela, Kleinhans Karin N, N'kontchou Gisèle, Scheffold Annika, Bauer Kerstin, Kratzer Ramona F, Kloos Natalia, Katz Sarah-Fee, Song Zhangfa, Begus-Nahrmann Yvonne, Kleger Alexander, von Figura Guido, Strnad Pavel, Lechel André, Günes Cagatay, Potthoff Andrej, Deterding Katja, Wedemeyer Heiner, Ju Zhenyu, Song Ge, Xiao Feng, Gillen Sonja, Schrezenmeier Hubert, Mertens Thomas, Ziol Marianne, Friess Helmut, Jarek Michael, Manns Michael P, Beaugrand Michel, Rudolph K Lenhard

Abstract excerpt

UNLABELLED: Telomere shortening impairs liver regeneration in mice and is associated with cirrhosis formation in humans with chronic liver disease. In humans, telomerase mutations have been associated with familial diseases leading to bone marrow failure or lung fibrosis. It is currently unknown whether telomerase mutations associate with cirrhosis induced by chronic liver disease. The telomerase RNA component...

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Identifiers

PMID: 21520174
DOI: 10.1002/hep.24217

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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