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Article

Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter.

The Biochemical journal - 1 Mar 2000

Gitan R S, Eide D J

Abstract excerpt

The yeast ZRT1 zinc transporter is regulated by zinc at both transcriptional and post-translational levels. At the post-translational level, zinc inactivates ZRT1 by inducing the removal of the protein from the plasma membrane by endocytosis. The zinc transporter is subsequently degraded in the vacuole. This regulatory system allows for the rapid shut off of zinc uptake activity in cells exposed to high zinc...

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PMID: 10677350
PMCID: PMC1220857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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