Article
Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families.
Human molecular genetics - 1 Apr 1999
Shai R, Quismorio F P, Li L, Kwon O J, Morrison J, Wallace D J, Neuwelt C M, Brautbar C, Gauderman W J, Jacob C O
Abstract excerpt
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune diseases. Its genetic component has been suggested by familial aggregation (lambdas = 20) and twin studies. We have screened the human genome to localize genetic intervals that may contain lupus susceptibility loci in a sample of 188 lupus patients belonging to 80 lupus families with two or more affected relatives per family using the ABI...
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