Article
Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
American journal of human genetics - 1 Feb 2000
Ober C, Leavitt S A, Tsalenko A, Howard T D, Hoki D M, Daniel R, Newman D L, Wu X, Parry R, Lester L A, Solway J, Blumenthal M, King R A, Xu J, Meyers D A, Bleecker E R, Cox N J
Abstract excerpt
After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped for selected markers....
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