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Article

Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Dec 1999

Jalal S, Wretlind G, Gotoh N, Wretlind B

Abstract excerpt

The gene mexR regulates negatively the expression of the MexA-MexB-OprM efflux pump in Pseudomonas aeruginosa, and mutations in mexR cause a multiple antibiotic resistance phenotype. Five hundred and forty resistant clones of P. aeruginosa PAO503 were isolated after selection for resistance to chloramphenicol or tetracycline. All isolates showed similar phenotypes and were resistant to tetracycline,...

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Identifiers

PMID: 10660141
DOI: 10.1111/j.1699-0463.1999.tb01516.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa.PMID 10660141Read ↗

A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.Semantic proximity Read ↗

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Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.Semantic proximity Read ↗

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosaSemantic proximity Read ↗

Evidence of MexT-independent overexpression of MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa in presence of metabolic stress.Semantic proximity Read ↗

Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump.Semantic proximity Read ↗

nfxB as a novel target for analysis of mutation spectra in Pseudomonas aeruginosa.Semantic proximity Read ↗

Role of the MexEF-OprN efflux system in low-level resistance of Pseudomonas aeruginosa to ciprofloxacin.Semantic proximity Read ↗

Mutations in NalC induce MexAB-OprM overexpression resulting in high level of aztreonam resistance in environmental isolates of Pseudomonas aeruginosa.Semantic proximity Read ↗

MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719.Semantic proximity Read ↗

Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa.Semantic proximity Read ↗

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