Article
Dependence of CD8+ T-cell-mediated suppression of HIV type 1 on viral phenotypes and mediation of phenotype-dependent suppression by viral envelope gene and not by beta-chemokines.
AIDS research and human retroviruses - 20 Jan 2000
Chen Y, Dampf D, Chen M, Kulka K, Volsky D J, Saha K, Gupta P
Abstract excerpt
CD8+ T-cell-mediated HIV-1 suppressive activity has been shown against a number of strains of HIV-1 and HIV-2. In this study using a semiquantitative assay, we showed that CD8+ T cells from seropositive subjects and herpes virus saimiri transformed CD8+ T-cell clones from HIV-1-infected subjects exhibited 5 to 100-fold higher suppressive activity against slow replicating nonsyncytia-inducing strains (Slow/NSI) as...
Topics
- CD4-Positive T-Lymphocytes
- Chemokines, CC
- Cohort Studies
- Cytotoxicity, Immunologic
- Giant Cells
- HIV-1
- Humans
- Phenotype
- T-Lymphocytes, Cytotoxic
- Viral Envelope Proteins
- Virus Replication