Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users.

The Journal of infectious diseases - 1 Aug 1998

Yu X F, Wang Z, Vlahov D, Markham R B, Farzadegan H, Margolick J B

Abstract excerpt

The characteristics of sequential human immunodeficiency virus type 1 (HIV-1) isolates from 12 seroconverters among injection drug users selected for either rapid or slow disease progression were evaluated. All 6 patients who developed AIDS within 5 years were initially infected with syncytium-inducing (SI) variants or showed a transition from non-SI-inducing (NSI) to SI variants. Detection of SI variants was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Peptide Fragments

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 9697718
DOI: 10.1086/515646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users.PMID 9697718Read ↗

Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis.Semantic proximity Read ↗

Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline.Semantic proximity Read ↗

Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression.Semantic proximity Read ↗

The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression.Semantic proximity Read ↗

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entrySemantic proximity Read ↗

Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells.Semantic proximity Read ↗

Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates.Semantic proximity Read ↗

Evidence for differences in MT2 cell tropism according to genetic subtypes of HIV-1: syncytium-inducing variants seem rare among subtype C HIV-1 viruses.Semantic proximity Read ↗

Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children.Semantic proximity Read ↗

Biological properties of HIV isolates in primary HIV infection: consequences for the subsequent course of infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.