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Article

Importance, mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors.

Cancer letters - 8 May 2002

Engelmann Carsten, Heslan Jean Marie, Fabre Monique, Lagarde Jean Pierre, Klatzmann David, Panis Yves

Abstract excerpt

GCV-ablation of transplanted TK-positive liver tumors or the application of syngenic and allogenic HSV-TK/GCV oncolysates significantly reduced the size of synchronously growing untreated sister tumors in the liver. These TK-negative liver tumors constantly showed an increased infiltration by mononuclears (x4). The relative abundance of CD 4/8, NK and monocyte subtypes remained constant. The distant bystander...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11880183
DOI: 10.1016/s0304-3835(01)00854-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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