Article
Correlations among p53, Her-2/neu, and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2000
Smith C A, Pollice A A, Gu L P, Brown K A, Singh S G, Janocko L E, Johnson R, Julian T, Hyams D, Wolmark N, Sweeney L, Silverman J F, Shackney S E
Abstract excerpt
Human solid tumors develop multiple genetic abnormalities that accumulate progressively in individual cells during the course of tumor evolution. We sought to determine whether there are specific sequences of occurrence of these progressive evolutionary changes in human breast cancers by performing correlated cell-by-cell measurements of cell DNA content, p53 protein, Her-2/neu protein, and ras protein by...
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