Article
Length rather than a specific allele of dinucleotide repeat in the 5' upstream region of the aldose reductase gene is associated with diabetic retinopathy.
Diabetic medicine : a journal of the British Diabetic Association - 1 Dec 1999
Fujisawa T, Ikegami H, Kawaguchi Y, Yamato E, Nakagawa Y, Shen G Q, Fukuda M, Ogihara T
Abstract excerpt
AIMS: To assess the possible contribution of a genetic factor to diabetic retinopathy. METHODS: (CA)n repeat length was investigated in the 5' upstream region of the gene coding for aldose reductase (AR), which is a key enzyme of the polyol pathway and plays a role in hyperglycaemia-induced tissu...
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