Article
Association of retinopathy with a microsatellite at 5' end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes.
Ophthalmic genetics - 1 Jun 2001
Lee S C, Wang Y, Ko G T, Critchley J A, Ng M C, Tong P C, Cockram C S, Chan J C
Abstract excerpt
Recent experimental data suggest that a microsatellite polymorphism at 5' end of the aldose reductase gene may be associated with the development of diabetic retinopathy. In the present study, we examined the allele distribution of the polymorphism in 384 Hong Kong Chinese patients who had late-onset (age at diagnosis > or =35 years) Type 2 diabetes, but no clinical evidence of cataract. Approximately 17% of them...
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