Article
Wild-type and mutant forms of v-src differentially alter neuronal migration and differentiation in vivo.
Journal of neuroscience research - 15 Jan 2000
Morgan J C, Majors J E, Galileo D S
Abstract excerpt
The effects of three different forms of v-src on brain cell development were determined in vivo. Recombinant retroviral vectors encoding the marker lacZ (control) and either wild-type v-src or SH2 or SH3 domain-deleted forms of v-src (deltaSH2 or deltaSH3, respectively) were used to infect neuronal progenitor cells in the embryonic chicken midbrain (optic tectum; OT). Embryos were injected in the OT with...
Topics
- Animals
- Cell Differentiation
- Cell Movement
- Chick Embryo
- Clone Cells
- Gene Deletion
- Gene Expression Regulation, Viral
- Genes, src
- Genetic Vectors
- Mutagenesis
- Neurons
- Phenotype
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Retroviridae
- Signal Transduction
- Superior Colliculi
- src Homology Domains