Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caldesmon isoform associated with phenotypic modulation of mesangial cells.

Experimental nephrology - 1 Jan 2000

Okamoto K, Kashihara N, Yamasaki Y, Kanao K, Maeshima Y, Sekikawa T, Sugiyama H, Murakami T, Makino H

Abstract excerpt

Caldesmon (CaD) is a major calmodulin- and actin-binding protein distributed in smooth muscle cells (SMC) and nonmuscle cells. There are at least two high-molecular-weight CaD (h-CaD) isoforms and four low-molecular-weight CaD (l-CaD) isoforms produced by alternative splicing. Isoformal interconversion is associated with phenotypic modulations of vascular SMC. We investigated the CaD isoform in human and rat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Calmodulin-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Glomerular Mesangium

Share to Glomerulonephritis

Share to Rats, Sprague-Dawley

Share to Rats, Wistar

Share to Thy-1 Antigens

Source

Identifiers

PMID: 10644879
DOI: 10.1159/000020644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caldesmon isoform associated with phenotypic modulation of mesangial cells.PMID 10644879Read ↗

The role of caldesmon in the regulation of endothelial cytoskeleton and migration.Semantic proximity Read ↗

Phenotypic changes of the mesangium in diabetic nephropathy.Semantic proximity Read ↗

Caldesmon over-expression in type 1 diabetic nephropathy.Semantic proximity Read ↗

[Phenotypic transition of smooth muscle cell and the expressional regulation of the caldesmon gene].Semantic proximity Read ↗

Transcriptional regulation of the chicken caldesmon gene. Activation of gizzard-type caldesmon promoter requires a CArG box-like motif.Semantic proximity Read ↗

Phenotypic modulation of the mesangium reflected by contractile proteins in diabetes.Semantic proximity Read ↗

Dystrophin (Xp21), a new phenotype marker of cultured rat aortic myocytes.Semantic proximity Read ↗

Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells.Semantic proximity Read ↗

Over expression of smooth muscle specific caldesmon by transfection and intermittent agonist induced contraction alters cellular morphology and restores differentiated smooth muscle phenotype.Semantic proximity Read ↗

Caldesmon mRNA splicing and isoform expression in mammalian smooth-muscle and non-muscle tissues.Semantic proximity Read ↗

Phosphorylated l-caldesmon is involved in disassembly of actin stress fibers and postmitotic spreading.Semantic proximity Read ↗

Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.