Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell.

doi:10.1099/0022-1317-81-1-161

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Article

Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell.

The Journal of general virology - 1 Jan 2000

Boehme K W, Williams J C, Johnston R E, Heidner H W

Abstract excerpt

The Sindbis virus mutant NE2G216 retains PE2 in place of E2 in its virion structure. NE2G216 is a host-range mutant that replicates with near-normal kinetics in vertebrate cells, but displays severely restricted growth in cultured mosquito cells (C6/36) due to defects in the virus maturation process. In this study we tested the hypothesis that the host-range phenotype of NE2G216 was linked to the differences in...

Topics

1-Deoxynojirimycin
Aedes
Animals
Antiviral Agents
CHO Cells
Cell Line
Cricetinae
Cytopathogenic Effect, Viral
Enzyme Inhibitors
Glycosylation
Mannosidases
Mutation
Oligosaccharides
Sindbis Virus
Ultracentrifugation
Virion

Source

Open in PubMed

Identifiers

PMID: 10640554
DOI: 10.1099/0022-1317-81-1-161

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